Complete Guide on Insulin-Like Growth Factor 1 (IGF-1)
What is the Insulin-Like Growth Factor (IGF-1)?
The Insulin-Like Growth Factor 1 is a compound that has a similar structure to insulin and its main function in the human body is to rejuvenate and reproduce body cells. Growth Hormones from the pituitary glands stimulate the liver to produce the insulin-like growth factor and together, they facilitate the growth of cells throughout the body which enables growth and development. IGF-1 also facilitates the strengthening of tissues, it increases bone density and it responsible for healing depending on what the body needs. With a deficiency of IGF-1, an infant will develop with stunted growth and numerous other health complications.
IGF-1 also controls the lifespan of organisms like worms, rats, and even fruit flies. Studies that were conducted on mice showed that inhibiting IGF-1 in some organisms can increase their lifespan by up to 55%, however, in human beings, there was no association between this factor and life expectancy. Unlike lab animals, human beings are always exposed to multiple infections, stress, and harmful environmental factors. Population studies looked into this relationship but different studies had conflicting results. In six studies, there was no notable association. Two studies showed a higher risk of dying and three studies showed a lower risk of dying with higher levels of IGF-1 in the body. It was however confirmed that having very low levels of IGF-1 in the body increases an individual’s risk of suffering and dying from numerous other medical infections. A lower level of IGF-1 in the body is more likely to become a health concern than higher levels of IGF-1. Nevertheless, maintaining a perfect balance of this hormone is the safest solution.
IGF-1 is responsible for many processes and activities in the human body. Apart from growth, IGF-1 plays an essential role in cell rejuvenation, tissue healing, repair, and immunity. Most individuals with chronic illnesses have lower levels of IGF-1 than normal, but there are many other surprising facts about IGF-1 that you are yet to find out.
The activities of IGF-1 are influenced by at least six other protein binding components with much influence coming from IGFBP-3 which can bind to more than 90% of IGF-1 in the body system. Though these two factors are correlated, there is much evidence to support the fact, IGF-1 acts independently on its effects on diseases like cancer and chronic illnesses.
Here are other interesting facts about IGF-1 that might surprise you.
- IGF-1 has anti-aging properties. Life expectancy can be predicted from the length of telomeres that are found in the human DNA. The quantity of IGF-1 in the body correlates to the length of telomeres in an individual’s DNA as confirmed by numerous tests that were carried out on healthy elderly men. In another case study, 525 people between 72 to 95 years old were found with higher levels of IGF-1 than the normal and they were associated with lower risks of dying within their next two years. IGF-1 also promotes the growth of brain cells which helps to prevent age-related cognitive decline. Old age is associated with less mobility, slower walking and declined muscle strength. These symptoms appear very early in individuals with low levels of IGF-1.
- IGF-1 increases antioxidants in body cells. IGF-1 has the ability to increase the levels of glutathione peroxide which is a very powerful antioxidant enzyme. IGF-1 protects body cells from radiation by increasing the effectiveness of the antioxidants, which prevents cell death. It is not advisable to increase your IGF-1 levels in case you are suffering from cancer or if you are partaking chemotherapy because this factor can prevent the cancer cells from dying and worsen your condition.
- IGF-1 is essential for the brain. In animal models, IGF-1 increased the levels of learning and memory. Other studies also confirmed that this factor has anti-depressant and anti-anxiety effects. IGF-1 has the ability to speed up mental processes, it can improve cognitive abilities and it prevents the accumulation of Amyloid plague in the brain. In people with Alzheimer’s disease, low levels of IGF-1 were associated with Dementia and a resistance to IGF-1 was accompanied by a resistance to insulin. IGF-1 increases the levels of BDNF in the human brain, which enables it to mimic the effects and results of exercise. IGF-1 can also prevent motor neuron diseases like Amyotrophic Lateral Sclerosis and with all these, it ensures optimum functioning of the brain.
- IGF-1 decreases inflammation and autoimmunity. Low levels of IGF-1 are associated with higher rates of inflammation. The administration of IGF-1 to mice delayed the onset of brain inflammation and autoimmunity, but when IGF-1 was administered after these diseases had developed, it worsened their symptoms. In mice, IGF-1 was able to reduce the symptoms of Type 1 Diabetes, Multiple Sclerosis, and Allergic Contact Dermatitis. Patients with HIV and inflammatory bowel diseases registered very low levels of IGF-1 and so was the case for patients with Lupus and Rheumatoid Arthritis. IGF-1 increases T-regulatory cells which help to tackle autoimmunity and decrease MCHI gene expression. Low levels of IGF-1 in the system can also lead to high levels of Histamine.
- IGF-1 will help you to build bigger muscles and avoid muscle wasting. IGF-1 is responsible for building muscles and it decreases the rates of muscle wasting. IGF-1 can help you to prevent muscle wasting due to old age and other factors.
- IGF-1 helps to balance blood sugar levels in the body. Metabolic syndrome is associated with low levels of IGF-1 in the system. In patients with Diabetes type 1, IGF-1 infusions can help create a balance of the blood sugars in their body by improving their body’s sensitivity to insulin and lowering triglycerides. Obese patients are more likely to have low levels of IGF-1, which makes them more resistant to insulin.
- IGF-1 can protect you against heart diseases. IGF-1 exhibits anti inflammatory effects on blood vessels. It can stabilize existing plague and it can help to reduce any additional accumulation of plaque. Coronary artery diseases and other cardiovascular diseases are associated with low levels of IGF-1 which also increases the risks of suffering from a stroke.
- IGF-1 promotes lengthening of bones and height. The activities of the growth hormones depend on IGF-1. A deficiency of this factor makes the body insensitive to the growth hormones and this interferes with growth. Poor growth and development in infants can be attributed to a deficiency of IGF-1, so it can be used to restore normal height, growth and development in such cases. Larson Syndrome, which is also a type of dwarfism, is associated with low levels off IGF-1.
- IGF-1 can be used to improve the density of bones. IGF-1 directly promotes the growth and development of bones but its anabolic/muscle binding effects can enhance bone density further because more muscle requires greater bone strength. High levels of IGF-1 are associated with a greater bone density.
- IGF-1 restores and maintains the gut. Treatment with IGF-1 done on animal models with Jaundice, Burns, and Colitis confirmed that IGF-1 can stimulate Mucosal DNA and protein content which can drastically reduce the incidences of bacterial translocation. IGF-1 can also improve the mucosal structure and the absorptive functions of the gut.
- IGF-1 can help you to clear bacterial infections. In animal studies, IGF-1 was able to clear Cystic Fibrosis from the lungs completely. IGF-1 can also be used to treat numerous other bacterial infections and it can improve survival rates in septic patients.
- IGF-1 can help to boost your immune system. IGF-1 increases the activities of the natural killer cells and it facilitates the multiplication of the B cells. This will automatically boost your immune system.
- IGF-1 can help you maintain an electrolyte balance. Studies that were carried out on elderly rats showed that IGF-1 can restore fluids in the body system which maintains an electrolyte balance.
- IGF-1 is healthy for your skin. IGF-1 can be used to protect the skin from aging because it is the most powerful stimulator of collagen biosynthesis. Reviving stagnant collagen and collagen synthesis can help prevent the skin from aging and dying.
- IGF-1 has the ability to inhibit urea. IGF-1 inhibits urea in the body system which leads to low levels of urea and nitrogen in the blood system.
The Negative Side Effects of IGF-1
Because IGF-1 acts by stimulating growth, it may have some negative effects especially to patients who are prone to cancer. IGF-1 can facilitate very powerful effects on all the stages of cancer development. It can enhance cellular proliferation, it can prevent the dying of cancer cells, it facilitates metastasis and angiogenesis and it can lead to more resistance to chemotherapeutic agents. IGF-1 binding proteins inhibit the effects of IGF-1. Only the free IGF-1 acts on the body, so both the IGF-1 and the IGF binding proteins should be considered for cancer cases.
- IGF-1 may contribute to the development of cancer. IGF-1 promotes an environment that is very conducive for breast cancer and it can enhance the resistance of cancer to cancer drugs and chemotherapy. IGF-1 increases the invasiveness of cancer cells. A review of 17 studies concluded that IGF-1 is positively linked to increased risks of breast cancer, prostate cancer, lung cancer and colorectal cancer. The levels of IGF binding proteins were also taken into consideration because of their effects on estrogen sensitive tumors. Some studies found out that both low and high levels of IGF-1 can increase a patient’s risks of succumbing to cancer. IGF binding protein 3 is responsible for balancing the level of IGF in the body. the In case of low levels of the binding proteins, free IGF-1 can facilitate growth and development that is abnormal and out of control. From this, cancer may develop.
- IGF-1 contributes to the development of acne. In both adult men and women, IGF-1 may influence the development of acne but it is more defined in women than in men. In men, testosterone and androgens play a greater role in the development of acne.
How to Increase Your Levels of IGF-1 Naturally.
If you are genetically predisposed to autoimmunity, or if you have low levels of IGF-1, you might want to focus more on the methods that can help you to elevate your levels of IGF-1. Some ways that you can increase your IGF-1 levels include; Taking a lot of calories, dietary proteins, fat, red meat, Calcium, dairy products, Casein, Vitamin C, Blue Berries, Growth Hormones, Estradiol, Res, Cinnamon, leucine, HMB, zinc, magnesium, Selenium, Astragalus, Eleuthero, Ursolic acid, Carnitine, Velvet and Soy Isoflavones.
How to inhibit/decrease the levels of IGF-1 in your system.
If you are genetically predisposed to cancer, or if you have very high levels of IGF-1, you should focus more on inhibiting your IGF-1. Some techniques that you can adopt include; fasting, more consumption of carbohydrates, reduced protein intake, intense walking, restricting your calorie intake, taking legumes, thyroid hormones, royal jelly, glucosamine, bilberry, luteolin, Curcumin, apigenin, genistein, and Tamoxifen.
Important notice on obtaining IGF-1
IGF-1 has recently been marked an R&D, Research and Development ONLY drug from the manufacturers. We have temporarily stopped compounding this drug until our legal team can get further clarification and we receive approval. Ipamorelin / CJC-1295 is the hot item at this time, and all our nationwide doctors have switched over to this product since. IGF1-LR3 is an amazing product because it increased your IGF1 levels which in return would boost GH levels. Our new product has similar effects with increasing your IGF1 levels and in return boosting GH levels. CJC 1295 is a synthetically produced peptide that can increase your plasma growth hormone levels. The main purpose of CJC-1295 is to boost protein synthesis levels and help fuel the growth of muscle tissues in the body. Many benefits will be derived by users who are incorporating CJC-1295 to their regimen; among these are:
Reduced body fat.Quicker recovery times post-injury.
Increased muscle mass.
Increase in strength.
It is used alongside Ipamorelin because of the synergistic effects and increased GH release levels.
An increase in growth hormone levels. These are naturally released by the pituitary glands, and as your body stops producing the hormone as you age, a supplement, such as Ipamorelin, can naturally help increase those dissipated levels.
If using it with CJC 1295, you can experience a correlation in increased muscle mass levels. With longer release periods, greater results are achievable. So, if you want to gain more muscle mass, or if you simply want to increase levels of lean muscle mass, you are going to realize these possibilities when you incorporate the use of Ipamorelin into your daily regimen.
Less downtime. You will recover faster, your body will recuperate faster, and you are back on your feet faster. So, you won’t experience as much downtime after a tough workout, letting you get back to your regimen faster.
Faster weight loss is achieved. Increase in lean muscle mass, increase in metabolic rate and increase growth hormones, all work together to help you burn more calories, and conversely lose more weight in less time.
Your skin, nails, and hair will look better. It can work to help fight the signs of aging, and you are going to look and feel younger. A younger, more jovial appearance is almost instantly realized among users who incorporate Ipamorelin to their workout and diet regimen.