Human Chorionic Gonadotropin (HCG) is naturally secreted by the placenta during pregnancy and commonly referred to as the “pregnancy hormone”. It is a hormonal substance that can be used to mimic and amplify the effects of two main endogenous gonadotropins, the Luteinizing hormone (LH) and the Follicle Stimulating hormone (FSH). The Human Chorionic Gonadotropin (HCG) is a chemical glycoprotein that is comprised of 237 amino acids. HCG has the exact structural properties and chemical characteristics and functions as the Luteinizing hormones (LH). Because of these similarities, many physicians prescribe HCG when a patient is in need of the physiological effects of the Luteinizing hormones. The LH and the HCG have the ability to bind to a common receptor, but HCG has a higher affinity for the receptors than the LH. Most people use HCG as medicine to lose weight and have had great results.
The main reasons why HCG is preferred over the Luteinizing hormone is because it is more stable in nature so it forms more stable bonds. It has a greater affinity for the receptors compared to the Luteinizing hormones so it bonds easier and quicker, it has higher and greater rates of physiological processes and activities with a longer lifespan than the Luteinizing hormone. The HCG can live to perform its activities for hours while the LH has a half-life that exists only for minutes. The short half-life of the Luteinizing hormone is, however, essential for its functions since it facilitates short and periodic variations of its exposure to the body. The HCG’s longer half-life span and its higher affinity for receptors, including its binding abilities, are some of the factors that enable it to be more biologically active than the Luteinizing hormones.
HCG on Testosterone Replacement Therapy
The Human Chorionic Gonadotropin (HCG) hormone regulates the fertility levels in males by binding to the receptors that are found in the male reproductive tissues. HCG is normally administered in conjunction with testosterone replacement therapy. When exogenous testosterone is administered to a patient, it affects the male reproductive tissues by creating effects and changes on the balance of the hypothalamus pituitary-gonadal axis (HPG-axis). Because of the various effects of the androgens and the influence caused by the aromatization of testosterone into oestrogen, a negative feedback is initiated, so the secretion and the production of endogenous testosterone is greatly reduced.
The negative feedback mechanism from the estrogen and androgens also reduces the secretion of the gonadotropic releasing hormones (GnRH), which in turn reduces the general secretion of gonadotropins. Gonadotropins are responsible for the general functions of the gonads i.e. hormone production and facilitating physiological activities around the male gonads. In simpler terms, the reduction in the production of the Follicle Stimulating Hormones (FSH) and the Luteinizing Hormones (LH) subsequently reduces the production of testosterone and limits the process of spermatogenesis in the testes. Testicular atrophy is experienced as a result of insufficient signaling of gonadotropins. HCG medication is therefore used during and after testosterone replacement therapy so that it can restore and maintain the size of the testicles, facilitate spermatogenesis and the continuous production of testosterone from the testes.
- Improves fertility levels in both men and women.
- Improves body composition by assisting in weight loss and management.
- Enhances fat oxidation.
ADVERSE REACTIONS / SIDE EFFECTS
- Headache, Irritability, Restlessness.
- Fatigue, Depression.
- Swelling in the feet, ankles, lower legs or hands.
- Female breasts in men.
- Pain in the area where you received the injection.