Hypothyroidism

What is Hypothyroidism

Hypothyroidism is a medical condition where the thyroid glands do not secrete enough of its two thyroid hormones as required by the body. The various factors that can impair the normal functioning of a healthy thyroid include; radiation therapy, drugs like lithium, genetic predisposition and some idiopathic factors. Both men and women can be affected by hypothyroidism but women are at a higher risk of acquiring this condition than men. Some signs and symptoms of hypothyroidism can be manifested through;

– Muscle aches, fatigue and pain, swelling or stiffness of the joints.

– A puffy face, dry skin and an unexplainable weight gain.

– A slower heart beating rate and elevated cholesterol levels in the blood.

– Menstrual periods that are irregular or heavier than normal in women.

– Constipation, hoarseness and thinning of hair.

– Impaired memory and depression.

The thyroid hormone exists in two forms. The prohormone thyroxine (T4), which is an inactive form of this hormone. It is produced exclusively in the thyroid glands and it has a 4th iodine molecule which contributes to its inactivity. The second form is the triiodothyronine (T3) which is created by removing the fourth iodine atom from T4. Only about 20% of the T3 in the body is produced by the thyroid gland. The rest is produced from the decomposition of the T4 at the various points and tissues where it is required the most.

The active form of this hormone (T3), functions to control the blood pressure and the rate of operation of the heart. An imbalance of the thyroid hormones, therefore, has abstruse effects on an individual’s cardiovascular health. Hypothyroidism is the leading cause of the health problems related to cholesterol accumulation in the body. A drop in the T3 levels in the blood leads to the abnormal functioning of the liver, so it produces excess fatty acids, cholesterol and triglycerides. This gradually increases an individual’s risk of developing a heart disease or the Alzheimer’s disease. Additionally, T3 facilitates the production and release of neurotransmitters and the myelin so it is very important in facilitating the flawless development of the mind and mental health.

Because this hormone is responsible for very many crucial physiological processes in the body, the health and the normal functioning of the thyroid glands is a case of serious concern to all physicians and medical healthcare providers. When an individual starts showing any signs of hypothyroidism, physicians are advised to seek an immediate pharmaceutical solution in order to relieve the patient’s body off these effects.

Our pharmacy offers four classes of thyroid medications which are set to cover all the possible options of hypothyroidism treatment. Our medications are designed to meet all the specific needs of any patient. Some treatments that we have are in form of;

– The thyroid USP. This is a substance that has been isolated from a natural porcine thyroid. It offers patients both the T3 and the T4.

Levothyroxine sodium (T4). This is a synthetic T4 in the form of a sodium salt, it is the most commonly prescribed solution for hypothyroidism in the world.

– The liothyronine (T3). This is another synthetic T3 in the form of a stable sodium salt.

– Custom combinations of these two hormones and other additional factors for a combination therapy.

– Our pharmacy can also work with medical physicians and their patients to develop and compound a personalized formulation that caters for the specific needs of a patient for a combination therapy.

THE THYROID USP

The Thyroid USP/Desiccated natural thyroid can be found in varying strengths only in specialized compounding pharmacies. Thyroid USP powder specifications require that each gramme of the substance is compounded with 34.2 – 41.8 mcg of levothyroxine and 8.1 – 9.9 mcg of liothyronine. This should produce a T3: a T4 ratio of 4.22:1 with an acceptable variance of ± 10% which is the accurately specified amount that meets the strict standards of the U.S pharmacopoeia monograph. The most largely preferred brands like the Wes throid, Armour thyroid and the Nature throid have always adhered to these guidelines.

Although these brands are effective, they may include additional substances and ingredients like dyes, stabilisers, binders, and fillers that have the potential to affect some properties of this drug or cause concerns for the patients with numerous allergic and hypersensitive reactions. That is the main reason why our pharmacy formulates a gelatin capsule which contains only the desiccated thyroid and a natural cellulose filler.

Even though the compounding process of this drug can be very complicated and meticulous, our expert specialists carefully use all-natural powders to manufacture the thyroid USP. We develop specifically customized doses that are not available commercially. If you are already on a thyroid USP treatment with a unique dose, we will work and ensure that you don’t have to split your Thyroid USP tablets. In addition to that, if you have any concerns over the allergies or the side effects that can result from this drug, we can compound your doses according to the strengths that you require without including any of the foreign substances that can lead to the negative effects.

As long as we get your prescription, we will compound the thyroid USP in doses that will satisfy all your medical needs and emit all factors that any patient cannot tolerate.

LEVOTHYROXINE SODIUM (T4)

Due to the difference of a pig’s to a human’s ratio of T4: T3 which is 4.22:1 in pigs and 4.20:1 in humans and a substantial variation in T4 and T3 levels in human beings, a synthetic form of levothyroxine is preferred to the porcine thyroid hormones. In clinical pharmacological therapeutics, the synthetic T4 is always used because it has a more reliable hormone content.

The levothyroxine sodium is one of the most administered and frequently used forms of treatment for hypothyroidism because it can relieve T3 hormone deficiency by decomposing and losing one iodine molecule. It is only through the successful conversion of T3 into T4 that the body will reap the full benefits of this treatment. Unfortunately, there is a minority group of patients with hypothyroidism whose bodies are incapable of decomposing the T4 into T3. Since a larger majority can effectively benefit from this form of treatment, it has grown to be one of the most prescribed drug globally.

LIOTHYRONINE SODIUM (T3)

On the other hand, people whose bodies are not able to effectively convert T4 into T3 urgently require the administration of both the T4 and T3 in their treatment. Our pharmacy provides physicians with all the options for the treatment of this condition. A T3 deficiency cannot be treated if a patient’s body cannot decompose and convert T4 into T3, so we offer the desiccated thyroid that contains the T3 and the T4 in the accurate and required proportions.

Synthetic T3 is available commercially but only as an immediate-acting preparation. If misused, it may lead to the development of some undesirable effects like heart palpitations. For this reason, some medical practitioners and physicians choose to lower the quantity of T3 in a dose or administer it using a sustained release mechanism. Both treatments are readily available in our pharmacy.

It is not advisable to administer T3 as a monotherapy i.e by itself, to relieve the symptoms of hypothyroidism but some individuals prefer using it with claims that it works best for them. A monotherapy administration of T3 for hypothyroidism has been backed up by numerous claims that it can relieve some effects of this condition that the Thyroid USP and the levothyroxine don’t have much effect on. An interesting fact is that T3 is widely used and administered alone as a solution to combat some of the various forms of depression because of the indirect effects it has on the serotonin levels in the body. It is however not recommended as a monotherapy to relieve hypothyroidism. In summary, the information surrounding the use of liothyronine only for the treatment of hypothyroidism is not conclusive. But it can be used together with levothyroxine sodium in a process known as a ”combination therapy”.

A COMBINATION THERAPY

There are numerous case studies that back up the possible superiority of a combination therapy over other forms of therapy for the treatment of hypothyroidism. A combination therapy involves the use of levothyroxine sodium and liothyronine sodium. A lot of other studies have stated that there is no difference or additional benefits of a combination therapy. This inconsistency of information together with the possible side effects that can arise from the use of this therapy has led many experts to believe that there is no benefit of using the combination therapy for hypothyroidism.

Even though these studies are not conclusive, the 15% of patients in the hypothyroidism population provide a very compelling cause to justify the combination therapy. 85% of patients with hypothyroidism can successfully increase both their T3 and T4 levels from the administration of T4 only. The rest of the 15% cannot attain normal levels due to the fact that they have a different form of the gene DI02. This gene is not expressed appropriately in this group of people and as a result, it creates an enzyme type 2 deiodinase ( IDII) that cannot facilitate the effective conversion of T4 into T3 instead it forms a reverse T3 (r-T3) which can further deteriorate the functions of the thyroid.

The gene DIO2 is an excellent case study that provides basic reasons why the convention methodologies available may not be the best way to treat this condition.

CUSTOM THYROID SOLUTIONS FROM OUR PHARMACY

Because hypothyroidism is a condition that has many phases, it is never clear for any patient on what the best method of treatment is. The Thyroid USP, liothyronine, levothyroxine and their combinations all have unique and profitable effects and different disadvantages to different patients. For a specific patient to achieve an optimal health status and a better quality of life, it is essential that their health care providers and physicians have every additional resource that they can have, at their disposal to deal with this condition.

For this reason, our pharmacy will offer you with the most potent and flexible toolkit available. You can choose from the Thyroid USP, Levothyroxine and the liothyronine with a complete personalized option to control the dosage strength and composition. You can also pick out the binders, the fillers and you have other alternatives and the ability to decide whether or not to use an instant form of administration or a periodic release.

Though there have been cases where patients have experienced some negative and unpleasant effects from the combination therapy, there is commendable proof that a majority of the patients on this treatment will experience both qualitative and quantitative benefits and a relief from the hypothyroidism’s effects. Everyone requires a unique solution to their problems, but since more than 75% of hypothyroidism patients are on treatment and still have at least one symptom that that affects them to uncomfortable extents, it supports the idea that currently proclaimed methods of treatment have some gaps and there is space for improvement. A personalized compounding of this drug can be a good start on this journey.

FACTORS THAT YOU SHOULD CONSIDER IN RELATION TO THIS TREATMENT

Non-compounded medications/commercially available drugs are approved by the FDA for a reason. They have many positive properties that our pharmacy emulate and their strict profiles are designed to facilitate a standardised method and options that all physicians across the world can apply and use.

It is very important to remember that our personalized compounding solutions and our customized combination therapy has no purpose of, and is not geared towards replacing or declaring superiority over the other conventional methods, but it is meant to offer different patients and physicians additional options and all possible choices to aid in tackling the different effects and symptoms that are unique to different people. In some patients, the traditional and conventional methods will work just fine but for others, specific symptoms may persist or improve slightly when on this medication. This means that there is room for improvement.

In hypothyroidism cases, another frequently neglected issue that can determine the outcome and the benefits of this treatment is considering whether an extended release of the medicine or an instant administration of the therapy will work best for a particular patient. Our pharmacy enables physicians and their patients to be informed and have a say on this matter so that they can select a method that is certain to reap the maximum benefits. In many cases, an extended release has proved to provide better quality results but all other aspects should be considered and noted.

If you need any additional information on this medication and its administration, feel free to contact us at any time.

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