Insulin-like growth factor-1 (IGF-1)

What is IGF-1 (Insulin-like Growth Factor)

The Insulin-like Growth Factor is one of the endocrine hormones that is produced in the liver. The release of this hormone increases in the presence of the Human Growth Hormone. Numerous cells throughout the muscles of the human body are equipped with cell receptors that have a high affinity for Insulin-like Growth Factor. This makes this hormone one of the best growth hormones and a facilitator of general cell growth which it does by targeting different specific tissues and in more autocrine cell communication processes, it facilitates cell division.

3-d model of IGF-1

3D Model of IGF-1

Some Benefits Of the Insulin-like Growth Factor 1 and some of the reasons why it has substantial advantages to bodybuilders and athletes include:

– It facilitates protein synthesis in the body.
– It regulates the storage of fat and channels it to be used for the production of energy. This results in a noticeable fat loss.
– It has anti-aging factors which slow down aging. Aging is linked to negative health effects like heart failure, depreciated neuron functioning, and low brain cell regulation.
– It increases the regenerative properties of the body’s nerve tissues.
– It boosts Hyperplasia in muscle cells, which leads to fuller muscle tissues.

Side Effects Of IGF-1

It should be well noted that continuous administration of IGF-1 in high doses has been confirmed to cause hypoglycemia, but in this case, it is not as severe as that caused by insulin. It is also stipulated but highly debated that IGF-1 can increase the size of a tumor in cancer patients. Even though this factor might be true in patients with existing cancer cases, everyone should be aware that IGF-1 does not cause cancer. In fact, the human body requires IGF-1 to regulate heart functions, brain cell stimulation and to improve the functioning of the nervous system.
People with low IGF-1 levels generally have a lower protein count and a smaller lean body mass. This can be very unhealthy. You should also know that whenever you have a headache, you don’t need a whole bottle of painkillers. Equally, whenever you are on this medication, you should make sure that you administer it in the correct way so that you can avoid some ignorant mistakes and adverse side effects. For more information about this medication, feel free to contact us.

Dosing And Injections

IGF-1 LR3

This variant of IGF-1 should be taken daily for 7 days in a week. You should dose it at about 50 mcg to 150 mcg. Desensitization occurs at around 40 days or approximately 4 weeks. Injection sites can be targeted to specific groups of muscles in the body but IGF-1 LR3 is not very good at enhancing growth at specific sites. It travels throughout the body.

DES IGF-1

DES IGF-1 should be dosed multiple times in a day, most preferably, before you embark on your training activities. You should target specific sites and muscles with a dose of about 50 mcg to 150 mcg. Since DES IGF-1 has a very short half-life, desensitization can rarely be noticed. You should always ensure that you localize your target sites so that you aim at specific muscle groups. If you want to enhance your biceps, you should administer this injection right into your biceps.

Why should You Use IGF-1?

In simple terms, the weight gain that you will experience from the use of IGF-1 is not due to water weight. All your weight gain will be caused by actual muscle growth which is a long term effect. Compared to steroids which are overly known for putting on water weight and often leading to adverse side effects, you will not get 10 lbs from Insulin-like Growth Factors, but you will acquire a solid 1lb or 2 lbs gain after every one or two weeks which will be composed of actual heavy muscle.
The most important feature of IGF-1 is its ability to cause hyperplasia in the human body. The body of a person who is on steroids goes through hypertrophy, this means that they will only be increasing the size of the existing cells in their muscles. On the other hand, IGF-1 leads to hyperplasia which purports the growth and development of new cells in the muscles. You can put these new cells into use by hard work, muscle training and even by using steroids to make them bigger. Generally, you will accomplish much more in terms of muscle density and size at a normal genetic level compared to when you use steroids.

 

Protein Structure of IGF-1

Protein Structure of IGF-1

Variants Of IGF-1

There are two groups of IGF variants. These are IGF-1 LR3 and DES IGF-1 ( which can also be presented as IGF-1 DES). The half-life of IGF-1 is very short, and because of this, it is quickly destroyed by the body. This is the main reason why IGF-1 was modified to produce an amino acid analog IGF-1 LR3 which has a longer half-life.The other variant of IGF-1, DES IGF-1 is a truncated version of IGF-1 which is up to ten times more potent than IGF-1. Both of these IGF-1 variants are similar to IGF-1 but they have different modes of action. This feature allows them to function together in different and specific ways.

IGF-1 LR3

The half-life of IGF-1 LR3 is about 20 – 30 hours. It is more potent than the regular base IGF-1. Because it can be sustained in the body for more than a day, it efficiently binds to cell receptors in the muscle cells and activates cell communication which subsequently improves the growth rate of muscles all day long.

 

IGF-1 LR3 inhibits the movement of glucose into the body cells which facilitates fat burning and the use of fat in the body for the production of energy. Its long life of close to a day has made it a preferred variant by a majority of patients and physicians because site injections are never necessary. IGF-1 LR3 cycles the whole body and binds to the receptors on muscle cells then acts for about a day, so a daily administration of this dosage is strongly supported.

IGF-1 DES

DES IGF-1 is a shorter version of the base IGF-1 chain. This variant of IGF-1 is five times more potent than The regular base IGF-1. It has a half-life of about twenty to thirty minutes which indicates that it is a very delicate chain. The administration of DES IGF-1 should only be done exactly where you want to experience muscle growth. DES IGF-1 has a higher ability to stimulate hyperplasia in the muscles than IGF-1 LR3. In conclusion, this variant works best when used for site injections and not overall muscle growth.
In addition to these functions, DES IGF-1 is known to bind to receptors, in cells, that have been deformed by lactic acid. Lactic acid is produced in elevated amounts during training and vigorous activities. This characteristic of DES IGF-1 allows it to attach to mutated receptors which signal tissue growth even during training activities. DES can be used more frequently and for a longer time than IGF-1 LR3.

IGF-1 Vs HGH

When we check on facts, the growth hormone is actually a precursor to the IGF-1, but why choose IGF-1 over the Growth Hormones? Growth Hormones do not cause direct muscle growth but instead, they facilitate the growth of muscles by signaling the release of the IGF-1. The Human Growth Hormone can prove to be very expensive and to attain continuous and substantial results and muscle growth, you must use it together with insulin or other anabolic steroids. This makes IGF-1 and its variants a much more viable solution for a body builder who expects a pronounced growth of muscles and a solid recovery of damaged tissues in their body.

 

 

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