What is IGF-1 LR3

IGF-1 LR3 which is also known as Long R3 IGF-1 or the insulin like growth factor is a compound that is comprised of a family of peptides/proteins which collectively play a very important role in the growth and development of mammals. IGF-LR3 is a varied form of IGF-1 which is more potent than IGF-1 and it has a longer lifespan. Unlike IGF-1, IGF-1 LR3 does not bind to IGF binding proteins in the cells or tissues which enables it to perform its actions more efficiently and at a higher level, IGF binding proteins inhibit the biological actions of IGF-1 so IGF-1 LR3 has been chemically altered so that it does not bind to the IGF binding proteins. For this reason, IGF-1 LR3 is the most effective form of IGF-1. IGF-1 LR3 was specifically created to increase the activities of this peptide and it was a success because this form has shown to increase both the function and efficacy of this peptide.

Long R3 IGF-1 is a single, human recombinant, non-glycosylated, polypeptide chain that contains 83 amino acids with a molecular mass of 9200 Daltons. IGF-1 facilitates a majority of the growth promoting actions of the growth hormones and it is a longer lasting variance of natural human IGF-1 which has been manufactured with a purpose of supporting a large scale development of recombinant pharmaceuticals in the mammalian cell structure. Developmental studies indicate that the growth hormone does not directly stimulate the incorporation of sulfates into cartilage rather, it acts through a serum factor that was previously known as the sulphation factor but Is now known as Somatomedin.

IGF-1 LR3 is the principal protein that promotes the response of cells to the growth hormone and it also induces cellular growth activities. This compound also makes the body sensitive to insulin and it can facilitate muscle cell hyperplasia, which is the actual splitting of cells.

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Muscle Growth and the Sequence of IGF-1 LR3

The long LR3 insulin like growth factor is an 83 amino acid analog of IGF-1 which is comprised of a complete sequence of IGF-1 with a substitution of the Arginine(Arg) for a Glutamine acid (Glu) at the third position which gives it the code, R3. It also has an extension of an L3 amino acid at its B terminus and just like IGF-1, IGF-1 LR3 is very effective in inducing the growth and development of body cells. This change in sequence is what inhibits this form of IGF-1 from binding to IGF binding proteins and it also allows it to have a longer lifespan of about 20-30 hours. Some direct effects of the LR3 insulin like growth factor include; increasing the transport of amino acids to cells, decreasing the degradation of proteins and increasing protein synthesis. When IGF-1 is active, it acts differently in different tissues. Apart from facilitating the synthesis of proteins and the absorption of amino acids, in the muscle cells, active IGF-1 also stimulates cell proteins and other associated cell components. IGF-1 can also act as a source of energy by mobilizing fat in the adipose tissues, which can be used to produce energy. In the lean tissues, IGF inhibits the transport of glucose across the cell membranes which forces the cells to turn to fat as their alternative source of energy.

IGF-1 LR3 facilitates the development of new muscle tissues by promoting the synthesis of proteins and nitrogen retention. This leads to the growth of muscles through hyperplasia which is an increase in the number of muscle cells and mitogenesis, which is the growth of new muscle fibers. IGF-1 LR3 not only enhances the growth of muscle fibers, but it also facilitates the development of new ones. This means that IGF can change the genetic capabilities of muscle tissues and increase the general cell counts in the muscles.

Some studies that were carried out on transgenic and knockout mice showed that IGF can control the body’s growth and development. It plays a very important role as a regulator in the GI-S phase of the cell cycle. When applied to cardiomyocytes, IGF-1 LR3 increases the expression of the proliferating cell nuclear antigen and after several cyclins, it was responsible for cell progression and bromodeoxyuridine labeling. Other effects of the IGF-1 LR3 in the cells included increasing the cells survival rates, inhibiting apoptotic pathways, increasing the recombination of proteins, their production, and longevity.

In another study, the administration of IGF-1 LR3 lead to an increase in the uptake of myocyte bromodeoxyuridine by three to five folds and it showed that the action of IGF-1 LR3 was blocked by P13K and ERK labeling which alternatively abolished the uptake of BrdU. In addition to this, IGF-1 LR3 also stimulated the division of cardiomyocytes in vivo.

In another investigation, IGF-1 LR3 was administered at different amounts to investigate its effects on the somatotropic axis. Reports from this study concluded that the long LR3 levels in the plasma increased when this drug was administered subcutaneously but no changes were noted when it was administered orally. In addition to this, IGF1-LR3 lowered the levels of endogenous IGF-1 and rBGH in calves, but it increased the concentration levels of IGF-II when administered subcutaneously. The parenteral administration of IGF-1 LR3 decreased the concentration of the human growth hormones but it had no effect on its secretory system. Final reports concluded that the somatotropic axis in neonatal calves is basically functioning and it can be influenced by the growth hormones, nutrition, and IGF-1 LR3.

IGF-1 LR3 has a longer lifespan than any other form of IGF-1 which is around 20-30 hours. Active IGF-1 plays a very important role in muscle renewal and it encourages the differentiation and development of stem cells. IGF-1 LR3 increases the activities of satellite cells, the content of muscle proteins, cross-sectional area of muscles, muscle weight and it also influences muscle DNA. The main reason why IGF-1 LR3 is very important is that all its effects work together to induce the growth of muscles. These effects can be enhanced further when combined with muscle training.

The most remarkable influence of IGF-1 LR3 on the human body is its ability to facilitate hyperplasia. Hypertrophy is usually the end result of weight training, which is just an increase in the size of muscle cells. Adults have a fixed number of muscle cells and all of them can become larger with training. However, the number of cells in their muscles can be hardly increased. With a preparation of IGF-1 LR3, an individual’s muscles will be able to induce hyperplasia which is the actual splitting and differentiation of cells. Research and various studies have shown that with adequately sustained weight training, these new cells can develop faster to become stronger and dense.


IGF-1 LR3 in Clinical Research

IGF-1 LR3 plays a very important role in the growth and development of human beings. This peptide is produced throughout a person’s lifespan but it is produced at the highest levels during puberty. In most studies concerning the action of this peptide, the maximum active period for research is usually 50 days. The most common range of administration is between 20mcg and 120mcg daily. At puberty, IGF is solely responsible for the natural growth of muscles. For more information, feel free to contact us.

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