Pyridoxine HCL

Pyridoxine HCL Uses

Pyridoxine HCL is usually prescribed for: nutritional supplementation

The only existing dosage form for Pyridoxine HCl is Injection Solution. Absolute Pharmacy injection solutions combine under the strict standards of USP 797 in order to ensure sterile constitution. The endotoxin, potency as well as the pH tests is performed in each batch. Their elaborate procedures ensure the quality and consistency of each compound they dispense.

Pyridoxine, or vitamin B6, is a natural, water-soluble vitamin. Some of the common sources include legumes, cereals, vegetables, meats and eggs. Since it is a rich source of Vitamin B, it is primarily used to fight vitamin B deficiency as well as to prevent or treat the toxicity of isoniazid, cycloserine or hydralazine. It is also efficient in the control sideroblastic anemia related to altered levels of serum iron. It has also been used in neonates to treat seizures and in patients with metabolic disorders such as primary hyperoxaluria, xanthurenic aciduria, primary homocystinuria, and primary cystathioninuria.

How Does It Work?

Vitamin B6 is composed of pyridoxamine, pyridoxine and pyridoxal. Pyridoxine is converted into erythrocytes at its active moiety, pyridoxal phosphate. On the other hand, pyridoxamine is converted to pyridoxamine phosphate.

These active forms act as coenzymes for over 60 metabolic processes including the metabolism of fat, protein and carbohydrates. When it comes to protein metabolism, its role incorporates amino acid decarboxylation, tryptophan conversion into niacin or serotonin, amino acid transamination and deamination.

Pharmacokinetics

Pyridoxine is given orally and by intramuscular or intravenous injection. The liver retains much of it, where it may also be phosphorylated while the muscles and the brain also retain minimal amounts.

The total body retention for adults is between 1630mg. Pyridoxal crosses the placenta, with fetal concentrations 5 times higher than maternal plasma concentrations. The half life of pyridoxine is 1519 days.

For nutritional supplementation in patients receiving NTP:
Intravenous dose:

There are no specific recommendations for adults, children and adolescents (weighing more than 40kg). However, it is recommended to add 10 ml / day of the preparation of adult intravenous parenteral multivitamins.

For neonates less than 2.5 kg, their recommended dose is 0.4 mg / kg / day IV mixed with TPN. Max: 1 mg / day.2

For patients with hepatic / renal impairment, there are no specific guidelines available for dose adjustments in hepatic impairment so it appears that no dose adjustment is required.

Modes of Administration

  1. Injectable administration: Pyridoxine is either given intramuscularly or intravenously. Parenteral therapy is reserved for patients for whom oral pyridoxine is not viable. As a general rule, you are advised to visually inspect parental products for particulate matter and discoloration prior to administration as long as the solution and container admit it. The parenteral solution should be preserved from light to avoid disruption.
  2. Intravenous administration: The recommendations here are that it be administered as a direct IV injection or as an alternate intravenous infusion in a standard IV solution. They can even be mixed into total parenteral nutrition (TPN) solutions that are compatible.
  3. Intramuscular Administration: This involves injection into a large muscle. One should also aspirate prior to injection so as to prevent injection into a blood vessel.

What Are The Contraindications?

1.Perrheral solutions of pyridoxine contain unstable concentrations of aluminum. Patients with renal impairment as seen in preterm infants risk toxicity as a result of aluminum buildup. The concentration of aluminum in parenteral solutions can be obtained by direct inquiry from the manufacturer.

  1. One should therefore ensure there is an appropriate intake of maternal pyridoxine (vitamin B6) during gestation. It is also observed that the pyridoxine requirement increases during pregnancy. In case of vomiting and nausea as a result of gestation, the FDA recommends an intake of 3 Pyridoxine (up to 40 mg / day) in combination with doxylamine. As at yet, there has not been any significant statistical relationships observed between fetal abnormalities and use during the first pregnancy.
  2. As Pyridoxine is secreted in human milk, appropriate maternal intake of it is vital during lactation, and there have been no problems with maternal supplementation to achieve adequate consumption goals during lactation.

Side Effects

Though considered non-toxic in regular doses, Pyridoxine has been associated with cases of nausea / vomiting, paresthesia, headache, hyperesthesia, drowsiness and low levels of folic acid in vaying degrees of intensity.

Chronic and excessive doses (26 g / day) are known to cause severe sensory peripheral neuropathy or a neuronopathy syndrome. On a more extreme end, convulsions have been reported in neonates following the administration of large doses of pyridoxine during pregnancy.

Points to Remember..

Do not share or take any other medication. Talk to your healthcare provider before starting any new medications, including over-the-counter products, natural products, or vitamins.

This medication was made specifically for you by Absolute Pharmacy. If you want to know more about it, talk to your doctor.

 

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