Nandrolone

Function

Nandrolone Decanoate is a drug prescribed for treatments of anemia, osteoporosis, AIDS – associated wasting syndrome and cachexia. It was approved by FDA in 1983.This drug stimulates appetite which reverses catabolic processes and negative nitrogen balance. Patients with cachexia experience increase in lean body mass while increased bone density in patients with osteoporosis was often shown. Increase in red blood cell volume and hemoglobin was recorded in patients with anemia associated with renal disease. Nandrolone Decanoate is used via injection in the muscle.

The drug can be given by a healthcare provider at any hospital, however, if you are able to do it yourself at home, you will be instructed on how to. After injecting, nandrolone decanoate gets hydrolyzed quickly and frees nandrolone by plasma esterases. It diffuses into cells very rapidly. This drug is metabolized in the liver, similar to testosterone. Upon injection, the drug is released from the intramuscular depot over four days. Intramuscular injection of anabolic steroids can cause inflammation, postinjection induration and furunculosis. Patients who notice any signs of an injection site reaction should contact their healthcare provider immediately.

Dosage

Absolute Pharmacy offers the best injection solutions used for this drug which meets all the requirements for sterility and safe usage. Every batch goes under pH testing before being used. The available dosage of nandrolone decanoate is 50 mL vial. 200 mg/mL. Dosage may vary depending on symptoms and how the patient is reacting to the drug. In some cases, dosage adjustment might be necessary to prevent severe issues.

If you have taken a larger dose than necessary, make sure contact the emergency room immediately. If you missed the injection, take it as soon as you remember. If it is almost time for the next dose, skip the previous one. Less is better than too much.

In case you are doing the injection by yourself, make sure you store the used injections in a special case. Never throw them in a trash or leave them around. If you don’t have any cases, contact your doctor or pharmacy to get some.

Misuse and side effects

Sorted in the category of androgens, this male sex hormone can produce adverse effects if misused. The abuse of this drug can cause changes in libido, increased risk of cardiovascular disease, hepatotoxicity as well as antisocial behavior. It has irreversible masculinizing effect on women. These effects can be stopped by ending the treatment when the first symptoms appear. However, continuing the treatment will cause irreversible masculinity.

Even in regular treatments, nandrolone decanoate can cause severe side effects such as changes in sex drive or performance, hair loss, headache, trouble sleeping or serious allergic reactions. Frequent usage of this drug can cause irregularities in the menstrual cycle as well. It is should never be used during pregnancy because the said effects might manifest on the fetus. It is not recommended to be consumed during the breastfeeding period either.

Male patients experience completely reverse effects since the inhibition of gonadotropin secretion causes androgens to convert to estrogens. However, these feminizing effects can be reversible. Excessive dosage of this drag leads to testicular atrophy, impotence, bladder irritation, epididymitis as well as excessive sexual stimulation. During longer periods of nandrolone decanoate in elderly patients the risk of prostate cancer increases. In immature males, this treatment can cause early virilism as well as premature epiphyseal closure.

In both males and females, there is a chance of developing peripheral edema which is caused by increased fluid retention. This therapy has shown results in hepatic necrosis and death as well. Even though these are very rare cases, the drug use should be ended immediately if cholestatic jaundice or hepatitis occurs. This therapy has induced osteolysis and can exacerbate hypercalcemia in some cases which include immobile patients and those suffering from metastatic breast carcinoma.

Observational studies and research among postmenopausal women, bodybuilders, and weightlifters who used anabolic steroids have show ‘pro-atherogenic’ changes in lipid profiles. Significant decreases in HDL concentrations and increases in LDL concentrations have shown that androgens such as nandrolone can produce greater lowering of this ratio that testosterone. Although the signs of hypercholesterolemia caused by androgens are unclear, patients who are predisposed to dyslipidemias or atherosclerosis should be treated with caution.

Precautions

Prior to taking this medication, you will have to be tested for any possible allergic reactions as well as conditions such as breast cancer, diabetes, heart disease, kidney disease or prostate trouble. Your blood will have to be tested before and during the therapy. It is shown that nandrolone decanoate affects blood sugar in patients with diabetes. Close monitoring of patients with this condition is necessary because the therapy can cause control loss over diabetes.

This drug should not be used with patients who have prostate or breast cancer due to increased growth of cancerous tissue. Androgens such as nandrolone decanoate can induce osteolysis which is why caution while treating patients with hypercalcemia is mandatory.

Your doctor should be familiar with all the medication you are and have been taking prior to starting nandrolone decanoate therapy. Other medication can interact with the drug and cause severe reactions which are to be avoided. Sudden ending of the therapy may cause different effects so patients who quit using this drug must be monitored carefully.

This type of drug can increase plasma concentrations of cyclosporine, which would lead to a greater risk of nephrotoxicity. Fluid retention is to be expected when using nandrolone decanoate which is likely to cause edema. Even though male sex hormones may be necessary to stimulate the growth when lacking human growth hormone, excessive doses of androgens such as nandrolone in immature males can speed up epiphyseal maturation.

It is well known that androgens stimulate erythropoiesis. This has been shown in patients with chronic renal failure, but other tissues besides the kidney can synthesize erythropoietin as well. Significant doses of androgens can increase the patient’s response to epoetin alfa, which ends up reducing the amount of medicine required to treat anemia. Different reactions to epoetin alfa have have resulted in large increase in blood viscosity, this drug combination should be strictly avoided.

General precautionary statements

Keep the medication away from heat and light, especially out of the reach of children. Never use the medicine after the expiration date and make sure you dispose it of properly. Never pour the medication down the drain or flush it in the toilet.

Always talk to your doctor about the symptoms you might be experiencing as well as previous and current conditions because this medicine will be dosed specifically for you. Do not share your medicine with anyone else nor take it from anyone else as this is very day.

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