Sermorelin

What is Sermorelin

The Growth Hormone Releasing Hormone that is also known as sermorelin acetate is a synthetic formulation of a naturally occurring substance that functions to stimulate the secretion of the Growth Hormone in the body. The growth hormone is primarily produced in the pituitary gland and it facilitates the normal growth and development of human beings from childhood to old age. Sermorelin acetate is principally administered to children who show the signs of stunted growth and those who do not grow at normal rates. This condition can be as a result of their bodies not producing sufficient growth hormones to facilitate normal growth. This medication can be used to restore normal growth hormone levels in Growth Hormone-deficient cases.

Sermorelin Chemical Structure

Sermorelin Chemical Structure

The History and background of Sermorelin

The structure of the Growth Hormone Releasing Hormone was first illustrated in 1970 by Nobel laureates, A. Shalley and R. Guilleman. After their description, William Wehrenberg who was one of their students sought out to determine the specific part of the molecule that was responsible for the stimulation of the pituitary gland to produce growth hormones. He eliminated individual amino acids and tested the remaining peptides until he came to a conclusion that only the first 29 amino acids were responsible for this effect. The chemical name for the molecule that facilitates the secretion of the growth hormones is GRH 1-29  NH2, the  NH2 is used to dictate the amino terminus of the molecule.

Particularly, sermorelin acetate is an acetate salt of a synthetic 29 amino acid peptide GRF 1-29  NH2 that exactly corresponds to the reactive amino acid segment of the natural GHRH which consists of 44 amino acid residues. Sermorelin is a non-pyrogenic, sterile, lyophilized powder which is designed for administration through injections in the subcutaneous layer of the skin after being reconstituted with bacteriostatic water. Sermorelin should be stored at 36F – 46F and away from direct sunlight, heat and children.

Indications of Sermorelin

Sermorelin is available in varying milligramme dosages which our pharmacy readily provides. We have non-customized vials of 3.0 mg, 6.0 mg, 9.0 mg and 15.0 mg. Sermorelin has been specifically indicated and approved for use in the diagnostic evaluation of pituitary functioning and to trigger and facilitate the production of the growth hormone by the pituitary glands in children. It can also be used to manage certain conditions like age-related growth hormone deficiency such as dwarfism and to prevent HIV- induced weight loss. Sermorelin acts by binding to the Growth Hormone Releasing Hormone receptors then acting in the same way as the original GHRH. It then facilitates and stimulates the secretion of the growth hormones.

Numerous clinical studies have been done to establish the properties of sermorelin. Some of its properties include; Maintaining the bioactivity in vitro and eliciting the secretion of an endogenous growth hormone in vivo

Side effects

Some of the most common side effects due to the use of sermorelin can include; Reactions on the injection sites, headaches, difficulty in swallowing, dizziness, hyperactivity, vomiting pale skin and tightness in the chest.

Some patients can develop some anti-GHRH antibodies at some point in their treatment. These antibodies work against the foreign GHRH but their effects cease after some period of treatment.

Conclusion

You should always notify your doctor or medical care provider of any negative or adverse reactions that you experience after the use of this medication as soon as possible. You should also let them know about all your current and previous medical conditions and any other drugs and substances that you are using.
For more information about this medication contact us immediately.

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