Tadalafil is primarily indicated for the treatment of Erectile Dysfunction, it also is used in the treatment of Benign Prostate Hypertrophy (BPH) and Pulmonary Arterial Hypertension (PAH). Tadalafil belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors and has similar properties to Vardenafil and Sildenafil. These drugs are often used to treat similar conditions.
- Helps relax the muscle in your prostate and bladder, this could help improve your BPH symptoms.
- Improve ED symptoms by increasing the blood flow to the genital area, which can help get and keeps erections as long as there is a level of sexual arousal present.
- Treats PHA by relaxing blood vessels, which increases blood flow to the area.
Tadalafil is not a prostaglandin inhibitor like other agents that are used to treat Erectile Dysfunctions and unlike Sildenafil, it does not lead to the development of visual disturbances and sensory conditions. When Tadalafil is used for the treatment of ED, its duration of action can last to up to 36 hours which is longer than the action span of both Sildenafil and Vardenafil. Since PDE5 inhibitors only facilitate an erection as a response to sexual stimulation, Tadalafil’s longer duration of action generates a more spontaneous sexual stimulation and sexual action. According to the guidelines for the treatment of ED, PDE5 inhibitors should be considered as the first line of treatment before looking for additional options.
Tadalafil was approved by the FDA for the clinical treatment of ED in 2003 and for the treatment of Pulmonary Arterial Hypertension in 2009. Clinical studies in patients with PAH showed an improvement in the activity and exercise capacity of their system and a diminished medical worsening of this condition during the treatment. In 2011, Tadalafil was approved by the FDA for the management of the symptoms of Benign Prostate Hyperplasia and for a concurrent treatment of ED and BPH.
Precautions that should be considered before taking Tadalafil:
Your healthcare service provider needs to be informed if you are suffering from the following conditions:
- Eye vision problems, bleeding disorders, a history of priapism (prolonged and painful erections).
- Angina, a history of cardiac conditions, high or low blood pressure or irregular heartbeats.
- Blood diseases, liver diseases, kidney diseases or allergic reactions to Tadalafil.
- Refrain from any sexual activities if you experience priapism, chest pains, dizziness, nausea, and pain in your arms upon initiation of sexual activities.
- A combination of Tadalafil with other medications that are used for the treatment of ED is not recommended because the safety and efficacy of such a combination has not been established.
- Tadalafil should not be used together with alpha beta blockers in the treatment of BPH because the efficacy of such a combination has not been established.
- Tadalafil is contraindicated in patients who are receiving a therapy that contains nitrates or nitrites due to the known effects of this drug on nitric oxide and the cGMP pathways. This drug has a huge potential for worsening the hypotensive effects of nitrate salts.
- Tadalafil is a PDE5 inhibitor and since PDE5 is found in blood platelets, this medication should be administered cautiously in patients with severe hematological diseases.
- Some possible chemicals and substances that can interact with Tadalafil, can be found in drugs that are used to treat high blood pressure, manage HIV/AIDS, yeast and fungal infections, seizures, and prostate problems. This list may not contain all the possible drug interactions, so it is advisable to inform your physician of all the medicines that you are currently using and this should include all the prescription and non-prescription drugs, vitamins, additives, and supplements.
ADVERSE REACTIONS AND SIDE EFFECTS
- Back pains, dizziness, flushing, indigestion, nausea.
- Muscle aches, running nose, irregular heartbeats.
- Changes in vision, changes in hearing and headaches.
- Hypotension, chest pains, angina, myocardial infarction.
- Palpitations, sinus tachycardia and syncope.
- Sudden strokes and cardiac deaths were also reported but these were in patients with a history of cardiac diseases.
- In patients with Pulmonary Arterial Hypotension, dyspepsia was reported more frequently.
- Viral gastroenteritis, nausea, diarrhea, abdominal pains and gastro esophageal reflex.
- Nasal congestion, gastritis, xerostomia, rectal hemorrhage, swelling of the eyelids, epistaxis.
- Ocular pain, increased lacrimation, blurred vision, tinnitus, facial edema, fatigue, and pain.