Tadalafil is a drug administered for treating patients with erectile dysfunction. It has a dosage strength of 10mg20mg. All Absolute Pharmacys’ troches are compounded following the strict USP 795 guidelines. We have a high quality and thorough assurance process that makes sure there is uniformity, potency and consistency for all the compounds dispensed.
The drug was approved by FDA for ED treatment in 2003, and in 2008 approval was given for it to be taken daily regardless of timing of sexual activity. When it comes to treatment of pulmonary arterial hypertension, FDA approved it in 2009.
Tadalafil is usually administered through the mouth to treat erectile dysfunction in males. It is also used in treatment of other health conditions including pulmonary arterial hypertension, BPH, benign prostatic hypertrophy and also in concurrent treatment of ED.
Unlike most other agents used in treating erectile dysfunction, this drug does not does not hinder prostaglandins.The drug is also recommended because it does not lead to visual disturbances associated with most other drugs used in treating erectile dysfunction.
How Tadalafil works
In order for the penis to erect, there is the production of nitric oxide from the corpus cavernosum when one is stimulated sexually. The nitric oxide released then activates guanylate cyclase leading to higher levels of cyclic guanosine monophosphate, which leads to smooth relaxation of muscles in the corpus cavernosum, leading to easy flow of blood. Tadalafil boosts the influence of nitric oxide by hindering PDE5, leading to high levels of cGMP that leads to better erection, although sexual stimulation is needed.
Tadalafil also inhibits PDE5 in the tissues of the lungs and the esophagus smooth muscle. Inhibition of PDE5 that occurs in the lung tissues makes the pulmonary vascular smooth muscle to relax. This also leads to pulmonary vasodilation, making the drug effective in treatment of pulmonary hypertension.
Administration of the drug
The drug is usually administered through the mouth. Once it gets fully absorbed in the body, it is distributed to the different body tissues. It is usually excreted from the body in form of metabolites, mostly in feces and small amounts in urine.
Precautions and contraindications
Before this drug is administered, it is important for the doctor to check if a person suffers from vision problems, bleeding disorders, priapism, angina, heart disease or has a history of irregular heat beat or heart attack. Other problems include liver disease, kidney disease, stroke or allergic reactions because of taking the drug itself.
In case you experience vision problems after taking the drug, you need to contact your doctor immediately. On the other hand, in case your erection lasts for more than four hours or you feel pain, you need to call your doctor. If you experience arm pain, chest pain, dizziness, nausea or feel pain just when you start the sexual activity, you need to stop and call your doctor.
When you are taking Tadalafil, you should not take alcohol because it just increases the risk of feeling dizzy or headache. You should also note that this drug does not protect you from sexually transmitted disease. Patients with health problems such as renal impairment, hepatic disease, cardiac problem, and visual problems should also take great precautions before taking this drug.
Tadalafil is known to interact with high blood pressure drugs, certain HIV drugs, drugs for yeast infections, drug for seizures, antibiotics and prostate problem drugs. It advisable to inform your doctor of non prescription drugs, herbs, medicines and other dietary supplements you might be taking. It is also good to avoid grape fruit juice that is known to reduce metabolism of drugs in the body.
Some of the side effects associated with this drug include headache, muscle aches, flushing, runny nose, nausea, back pain and dizziness. In case you experience allergic reactions such as hives, itching, breathing problems, chest pain, swelling of face, seizures and erection lasting more than four hours, you need to call your doctor.
The best way to take it
Tadalafil should be taken orally, following the directions given on the label. It is possible to take it with or without meals. If you want to take it to treat erectile dysfunction, you might be advised to take it on daily basis or as needed. If you take it as needed, them you need to engage in sexual activity half an hour after taking it. Regardless of the way you take it, you should never overdose it unless you are advised to do so by your doctor. In case you miss a dose, take it immediately when you remember.