The Bi-mix is a penile self-injection medication that is classified under some of the most powerful anti-erectile dysfunction agents. Even though the components that make up the Bimix solution are individually indicated for numerous other conditions, the practice of combining these drugs for the treatment of Erectile Dysfunction disorder has been widely adopted in clinical medicine. Because of this combination’s very high success rates, it is considered one of the best alternatives to PDE5 inhibiting drugs, especially for patients who are not responsive to the standard PDE5 inhibiting drugs.
Bimix is primarily indicated for the treatment of erectile dysfunction disorders and it is made up of two medications with components that are designed to act co-operatively when mixed into a sterile injection. These drugs are Papaverine and Phentolamine. We also sell Trimix injections which are a combination of Prostaglandin, Papaverine, and Phentolamine.
Papaverine is a medication that leads to the vasodilatation and vasoconstriction of blood vessels in the body tissues. This means expansion and contraction of blood vessels. It facilitates an erection by allowing more blood flow into the penis. Numerous experiments carried out on dogs showed that Papaverine increases the flow of blood into the penis through vasodilation of the arteries and decreases the flow of blood out of the penis by vasoconstriction of the veins. Papaverine interacts with adenylate cyclase which results in an increased production of cyclic adenosine monophosphate. This ultimately facilitates an increased penile capacity to hold blood by relaxing the smooth muscles in the penis. Papaverine also works by inhibiting phosphodiesterase. Unfortunately, this drug has numerous other modes of action that have not been sufficiently established. Papaverine is one of the first effective treatments for erectile dysfunctions that is administered by a penile injection.
50 patients aged between 40 years to 70 years were administered 60 mg of Papaverine in 5 ml saline at the base of their penis after every 2 weeks. The results showed an erection of 80% and more in all of the patients except one. This clearly indicates that Papaverine improves sexual potency.
In a double-blind controlled trial for the treatment of impotence using Intra penile injections of papaverine and phenoxybenzamine, 39 patients aged between 27 years to 67 years old were given an intracavernosal injection of 60 ml Papaverine in saline. 35% of them experienced a full restoration of their erectile capacity and 65% of them experienced a partial restoration of their erectile capacity which further supports this concept.
Phentolamine is a medication that can be individually administered to the penis. It facilitates an erection by elevating cardiac output and dilating/ relaxing the blood vessels of the penis. Phentolamine is classified under Alpha-adrenoceptor antagonists. Noradrenaline causes the smooth muscle toning of the penile tissues by maintaining the corpora carvenosa in a contracted state. By inhibiting the noradrenaline receptors, an erectile response is achieved. Phentolamine has the same binding capacity to the alpha-1 adrenoceptors and the alpha-2 adrenoceptors so it competes for the binding sites with the endogenous noradrenaline. This is presumed to be the main mechanism of action through which phentolamine applies its physiological effects.
The alpha-antagonists of phentolamine are very complex. The non-selective action of blocking receptors interacts with adrenergic nerves in a very complex design but the action of phentolamine on adrenergic nerves has not been fully established. It is however assumed that there might be some counteractive regulation on the pre-junctional and the post-junctional nerves but it is not known how this regulation affects the efficacy of phentolamine in the treatment of E.D.
Studies in animals have indicated a decreased resistance to the penile arterial inflow which proves that the body’s physiological response to phentolamine is geared towards achieving an erectile response. Nevertheless, phentolamine does not show any significant effects on the venous outflow of blood in the penile tissues of human beings. Current research has not completely established the pharmacokinetics of phentolamine.
Phentolamine has minimal side effects which are very rare but there are reports that tachycardia, Orthostatic hypertension, myocardial infarction, and arrhythmias may occur after its administration.
20 patients who are aged between 32 years to 72 years old were administered with a 30 mg papaverine and 1 mg phentolamine and the results showed that 18 out of 20 subjects responded with an erection that was sufficient for a complete sexual intercourse in 20 to 30 minutes
You should never administer this medication if you are allergic to or if you react hypersensitively to any of the components in its formulation. You should avoid this medication if you are suffering from any condition that can predispose you to priapism ( this is a painful erection that can last for more than 4 hours ). Avoid it if you are suffering from sickle cell anemia, leukemia, anatomical penile deformation or if you have undergone a penile implant. You should also avoid this medication if you have instructions from your doctor to abstain from sexual activities.
Avoid this medication if you are on any drugs that can interfere with blood clotting and make sure that you inform your doctor of any medical conditions that you have ever been diagnosed with and those that you are currently treating.
Basically, this medication should be administered just before foreplay via an intracavernosal injection on the penis. It is expected to produce an erection in about 5 to 20 minutes and this erection can last up to an hour. To prevent bruising, make sure that you apply pressure firmly onto the point of injection for at least five minutes after the injection. You should not use this medication more than two times in a week and all your administrations should be at least 24 hours apart. This medication should only be administered before sexual intercourse and you should never take a double dose or extra doses.
Some side effects of the Bimix can include; mild to moderate pain at the injection site during injection, a painful sensation during the erection and a small amount of bleeding on the injection site. You should contact your health service provider immediately in case you notice any swelling, redness, lumps, a curvature of the penis or tenderness. Make sure that you administer the injection correctly to avoid needle breakage. In case the needle breaks, contact emergency services immediately.
The Bimix medication is very unstable at room temperature and once it is reconstituted, it should be stored in a refrigerator at temperatures below 5 degrees. It should, however, be noted that the improper storage of this medication will not result in any harmful chemical formulation but instead, it will substantially reduce its potency. For this medication to be most effective, it should stay fresh.
The Bi-Mix injection is generally prescribed for the treatment of erectile dysfunction in males. The dosage strengths available for the Bi-Mix in our pharmacy are 5 mL vial. Papaverine HCl 30mg/mL, Phentolamine Mesylate 1mg/mL and 5 mL vial. Papaverine HCl 30mg/mL, Phentolamine Mesylate 2mg/mL. But we can compound a mix with customized requirements that will best suit you.
The form available for the Bi-Mix medication is an Injection solution. Our Pharmacy compounds all injection solutions under the strict USP 797 guidelines for sterility. pH testing is performed on every batch before we release it. Our quality-assurance processes ensure that all our products are uniform and consistent. Contact us today for more information on this medication and its administration.