Trimix Injection, Dosage, Side effects, Instructions, Cost & Where to buy them online

 



TRIMIX INJECTIONS, DOSAGE,
SIDE EFFECTS, INSTRUCTIONS,

COST & WHERE TO BUY THEM ONLINE

What are
Trimix Injections made of?

Trimix Injections include a mixture of 3 drugs. These are Papaverine,
Alprostadil/Prostaglandin, and Phentolamine.
Trimix injections are considered
as one of the most powerful classes of anti-erectile dysfunction medications.

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Papaverine

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Alprostadil/Prostaglandin

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Phentolamine

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Even though the components that make up Trimix Injections are often individually indicated for numerous other conditions, when used together, they affect a powerful action that is sufficient for the treatment of Erectile Dysfunction.

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Dosage Of Trimix Injections

The initial dosage of Trimix Injections should be around 0.05cc to 0.2cc which should depend on a patient’s level of erectile dysfunction.

You should wait for at least 48 hours before you increase your dosage. After this, you can increase your dosage by 0.025cc to 0.05cc until you arrive at a satisfactory level. The maximum dose should be 0.5cc.

The initial dose is kept low in order to avoid a prolonged erection, so you should not be discouraged if you get poor results within your first few attempts.

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This medication can be customized according to a patient’s needs and Absolute Pharmacy will work together with you and your physician so that we can develop the perfect Trimix shot that we will find most effective for you.
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The goal of using Trimix shots is to provide you with an easy to use, safe and reliable method and achieving and maintaining an erection that is sufficient for a satisfying sexual relationship.
Instances when you should avoid using Trimix Injections for Erectile Dysfunction
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You should never take trimix injections if you are hypersensitive or allergic to any component in this formulation.

You should also avoid this medication if you have a condition that can predispose you to priapism (This is a painful erection that lasts for more than 4 hours).

Avoid it when you are suffering from sickle cell anemia, leukemia anatomical deformations of the penis, penile implants and if you have direct instructions from your physician to abstain from sexual activities.
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Precautions when using
Trimix Injections
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You should provide your healthcare provider with a list of all drugs that you are currently using including all non-prescription drugs, illegal drugs, and dietary supplements. Some chemicals in these substances can interact with your medication and render them ineffective or cause various negative effects…

How should Trimix Injections be administered?

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This injection should be administered just a few minutes prior to foreplay. It should be given through an intracavernosal injection and it should produce an erection in about 5 to 20 minutes.You should never take double or extra doses.

Possible side effects from this medication include mild to moderate pains during the injections, a small amount of bleeding at the injection site and a painful sensation during the erection.

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You should contact your health service provider immediately in case you experience any swelling, numbness, redness, tenderness, and lumps on your penis or its surrounding areas.

If your erection lasts for more than 2 hours, take 2 – 4 pseudoephedrine tablets only once. You should then apply an ice pack. If this erection still persists after another hour, seek immediate medical attention.

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The three drugs that have been mixed in the Trimix shots include:

Papaverine

Papaverine is a nonsterile vasodilator. This means that it is a medication that facilitates the expansion of the blood vessels. Through this mechanism, it is able to facilitate an increased flow of blood into the penis.

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Papaverine interacts with adenylate cyclase which results in an increased cyclic production of adenosine monophosphate.

Ultimately, this causes an increased erectile capacity by relaxing the smooth muscles of the penile. This medication was one of the first effective treatments for erectile dysfunction that is administered through a penile injection.

Papaverine works by inhibiting phosphodiesterase. There are multiple other mechanisms and modes of action by which this drug works to facilitate an erection but they have not been sufficiently established, though it has been stipulated that the multi-mechanistic characteristics of this drug might depend on its concentration.

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Data from various experiments have proved that Papaverine acts to relax penile arteries, the cavernosal Sinusoids and the veins of the penis.

Various experiments that were carried out on dogs displayed this drug’s ability to decrease the resistance of the flow of blood into the arteries and increase the resistance of the flow of blood out from the veins.

50 patients aged between 40 to 70 years old were given a bi-weekly administration of 60mg papaverine in 5 ml saline.
This injection was administered at the base of their penis and it was meant for managing Erectile dysfunction.
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The results from this study showed that all individuals except one experienced an erection of 80% and more during this medication.

39 patients of age 21 to 65 years old were given an intracavernosal
injection of papaverine and phenoxybenzamine in a controlled trial. The
dosage was 60mg Papaverine in 10ml saline.

The results showcased a full restoration of erectile capacity in 35% of the patients and partial restoration of erectile capacity in 65% of the patients.

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Phentolamine

When Phentolamine is injected into the penis, it induces an erection by relaxing and dilating the blood vessels of the penis and elevating cardiac output. Phentolamine is classified as an alpha-adrenoceptor antagonist. Noradrenaline affects a smooth muscle toning of the penile tissues by keeping the corpora cavernosa in a contracted state.

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  • By blocking the adrenaline receptors, the alpha-adrenoceptors are inhibited and an erectile response is achieved.
  • Phentolamine competes with the endogenous norepinephrine for the alpha-adrenoceptors.
  • The latest medical literature suggests that it is through this mechanism that it exerts its physiological effects.
  • Phentolamine also blocks 5-HT receptors which induce the release of histamine from the mast cells.

Other studies suggest that the activation of NOS might also be another possible
mechanism of action.

Prostaglandin

Prostaglandin is a powerful hormone like substance which induces an erection by relaxing the blood vessels in the penis and dilating cavernosal arteries. This dilation is accompanied by an increase in the arterial inflow which allows more blood to move into the penis and a resistance to venous outflow which retains more blood in the penis.

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Prostaglandin should be administered Intracavernosal and it is always prescribed as an alternative when orally administered PDE5 inhibitors are proved to be ineffective in managing an Erectile dysfunction.

Several aspects of this drug have been investigated and currently, data suggests that 40% to 70% of patients with erectile dysfunction respond to this drug on medication.

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It has not been fully established why some patients do not respond to prostaglandin but a combination of prostaglandin and S-nitro glutathione has proven to be more effective in treating an erectile dysfunction than using prostaglandin alone.

It has not been fully established why some patients do not respond to prostaglandin but a combination of prostaglandin and S-nitro glutathione has proven to be more effective in treating an erectile dysfunction than using prostaglandin alone.

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Prostaglandin has very rare to no side effects at all especially in the circulatory system because it has a very brief action time and a high rate of metabolism. Because Prostaglandin undergoes metabolism very fast, injections that are administered in the penile only affect the penile tissues.

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