Trimix is a mixture of 3 drugs. These are Papaverine, Alprostadil/Prostaglandin, and Phentolamine. Trimix is considered as one of the most powerful classes of anti-erectile dysfunction medications. Even though the components that make up Trimix are often individually indicated for numerous other conditions, when used together, they affect a powerful action that is sufficient for the treatment of Erectile Dysfunction. For this reason, they have been used extensively for decades in the management of erectile dysfunction where PDE5 inhibitors are contraindicated or non-responsive.
The initial dosage of Trimix Injections should be 0.05cc to 0.2cc which should depend on a patient’s level of erectile dysfunction. You should wait for at least 48 hours before you increase your dosage. After this, you can increase your dosage by 0.025cc to 0.05cc until you arrive at a satisfactory level. The maximum dose should be 0.5cc. The initial dose is kept low in order to avoid a prolonged erection, so you should not be discouraged if you get poor results within your first few attempts.
This medication can be customized according to a patient’s needs and Absolute Pharmacy will work together with you and your physician so that we can develop the perfect Trimix shot that we will find most effective for you. The goal of using Trimix shots is to provide you with an easy to use, safe and reliable method and achieving and maintaining an erection that is sufficient for a satisfying sexual relationship.
You should never take trimix injections if you are hypersensitive or allergic to any component in this formulation. You should also avoid this medication if you have a condition that can predispose you to priapism (This is a painful erection that lasts for more than 4 hours). Avoid it when you are suffering from sickle cell anemia, leukemia anatomical deformations of the penis, penile implants and if you have direct instructions from your physician to abstain from sexual activities.
You should provide your healthcare provider with a list of all drugs that you are currently using including all non-prescription drugs, illegal drugs, and dietary supplements. Some chemicals in these substances can interact with your medication and render them ineffective or cause various negative effects…
This injection should be administered just a few minutes prior to foreplay. It should be given through an intracavernosal injection and it should produce an erection in about 5 to 20 minutes. You should never take double or extra doses.
Possible side effects from Trimix include mild to moderate pains during the injections, a small amount of bleeding at the injection site and a painful sensation during the erection. You should contact your health service provider immediately in case you experience any swelling, numbness, redness, tenderness, and lumps on your penis or its surrounding areas. If your erection lasts for more than 2 hours, take 2 – 4 pseudoephedrine tablets only once. You should then apply an ice pack. If this erection still persists after another hour, seek immediate medical attention.
Our pharmacy has all the equipment required to customize your Trimix doses for you so that we can compound it to fit your specific needs. For more information & the cost of Trimix and its administration and where to buy trimix shots online, feel free to contact us.
Papaverine is a nonsterile vasodilator. This means that it is a medication that facilitates the expansion of the blood vessels. Through this mechanism, it is able to facilitate an increased flow of blood into the penis. Papaverine interacts with adenylate cyclase which results in an increased cyclic production of adenosine monophosphate. Ultimately, this causes an increased erectile capacity by relaxing the smooth muscles of the penile. This medication was one of the first effective treatments for erectile dysfunction that is administered through a penile injection.
Papaverine works by inhibiting phosphodiesterase. There are multiple other mechanisms and modes of action by which this drug works to facilitate an erection but they have not been sufficiently established, though it has been stipulated that the multi-mechanistic characteristics of this drug might depend on its concentration. Data from various experiments have proved that Papaverine acts to relax penile arteries, the cavernosal Sinusoids and the veins of the penis. Various experiments that were carried out on dogs displayed this drug’s ability to decrease the resistance of the flow of blood into the arteries and increase the resistance of the flow of blood out from the veins.
50 patients aged between 40 to 70 years old were given a bi-weekly administration of 60mg papaverine in 5 ml saline. This injection was administered at the base of their penis and it was meant for managing Erectile dysfunction. The results from this study showed that all individuals except one experienced an erection of 80% and more during this medication.
39 patients of age 21 to 65 years old were given an intracavernosal injection of papaverine and phenoxybenzamine in a controlled trial. The dosage was 60mg Papaverine in 10ml saline. The results showcased a full restoration of erectile capacity in 35% of the patients and partial restoration of erectile capacity in 65% of the patients.
When Phentolamine is injected into the penis, it induces an erection by relaxing and dilating the blood vessels of the penis and elevating cardiac output. Phentolamine is classified as an alpha-adrenoceptor antagonist. Noradrenaline affects a smooth muscle toning of the penile tissues by keeping the corpora cavernosa in a contracted state. By blocking the adrenaline receptors, the alpha-adrenoceptors are inhibited and an erectile response is achieved. Phentolamine competes with the endogenous norepinephrine for the alpha-adrenoceptors. The latest medical literature suggests that it is through this mechanism that it exerts its physiological effects. Phentolamine also blocks 5-HT receptors which induce the release of histamine from the mast cells. Other studies suggest that the activation of NOS might also be another possible mechanism of action.
The Alpha-adrenoceptor antagonizing action of phentolamine is very complex. The non-selective blocking of receptors interacts with the adrenergic nerves in a complex process that has not been fully established. It is presumed that a counteracting regulation of the prejunctional and the postjunctional nerves might affect the efficacy of phentolamine in treating erectile dysfunction.
Various studies on animals have showcased a decreased resistance in penile arterial inflow which indicates that the physiological responses of phentolamine are geared towards achieving an erectile response. In human beings, phentolamine does not display any significant effects on the outflow of blood from the veins of the penile.
The half-life of phentolamine is about 20 to 30 minutes and when in the body, it is effective for two and a half to four hours. After this injection, the concentration levels of phentolamine in the serum reaches its peak after 20 to 30 minutes then it undergoes rapid metabolism.
20 patients aged between 32 to 72 years old were given an intravenous injection Papaverine and Phentolamine at a dosage of 30mg Papaverine and 1 mg phentolamine. The results was a response with an erection in 20 – 30 minutes which was established in 18 out of 20 patients.
Prostaglandin is a powerful hormone like substance which induces an erection by relaxing the blood vessels in the penis and dilating cavernosal arteries. This dilation is accompanied by an increase in the arterial inflow which allows more blood to move into the penis and a resistance to venous outflow which retains more blood in the penis. Prostaglandin should be administered Intracavernosal and it is always prescribed as an alternative when orally administered PDE5 inhibitors are proved to be ineffective in managing an Erectile dysfunction. Several aspects of this drug have been investigated and currently, data suggests that 40% to 70% of patients with erectile dysfunction respond to this drug on medication. It has not been fully established why some patients do not respond to prostaglandin but a combination of prostaglandin and S-nitro glutathione has proven to be more effective in treating an erectile dysfunction than using prostaglandin alone.
Prostaglandin has numerous modes of action which control a lot of processes in many tissues. Some of its known effects include; the vasodilation of veins and arteries, it prevents the aggregation of platelets and it stimulates intestinal activities.
Prostaglandin has very rare to no side effects at all especially in the circulatory system because it has a very brief action time and a high rate of metabolism. Because Prostaglandin undergoes metabolism very fast, injections that are administered in the penile only affect the penile tissues.